GLOBAL HEALTH

SCIENCES

GLOBAL HEALTH
SCIENCES
Overview

Our Global Health Sciences team aims to lower costs, improve quality, and increase access to treatment for millions of people in resource-limited settings by helping to develop less expensive and more effective versions of critical medications for adults and children; developing techniques and technologies that advance our understanding and management of diseases; and improving patient care. Five teams within Global Health Sciences provide technical insight and solutions across CHAI-supported countries and programs as well as to commercial entities, regulatory and normative organizations, and academic partners.

Analytics and Implementation Research

The Analytics and Implementation Research team supports CHAI’s mission to transform global health through: evaluations that test effectiveness and cost of innovations in real-world health settings and measure success; models that calculate the expected impact and cost of health programs and strengthen government capacity to prioritize investments; implementation research that accelerates the implementation and scale-up of highly effective interventions; data solutions that strengthen health systems; and translation and dissemination of knowledge and credible results that inform national and global level policy. The team includes public health scientists with broad experience in biostatistics, epidemiology, economics, and disease expertise.

Clinical Sciences

Health care products are important to restore and maintain health, yet these products must be administered correctly to optimize benefits and minimize risks. The Clinical Sciences team develops strategies and technologies that advance our understanding of disease and improve the delivery of health services. We interpret and share trends and research in global health to ensure CHAI’s work is well-informed and impactful; train and mentor colleagues on treatment guidelines and standards of care in resource-limited settings; and develop global and national public health policies.

Product Development and Regulatory Affairs

The Product Development and Regulatory Affairs team works with academia, other NGOs, and innovator and generic pharmaceutical companies to develop and commercialize adult and pediatric drugs, diagnostics and medical devices across multiple diseases. We help accelerate research and product development by supporting the filing of regulatory dossiers that demonstrate a new product’s safety, efficacy, and quality.

Process Chemistry

The Process Chemistry team at CHAI performs independent research in our Philadelphia laboratories and collaborates with other laboratories around the world to develop new chemical manufacturing processes that are substantially more cost-effective than current ones.

Quality and Sourcing

The Quality Sourcing Cost Optimization team sources and costs medicinal ingredients to understand the key drivers of drug prices. We use these costs to guide price negotiations.

In addition, the team is responsible for quality assurance and control, ensuring that products CHAI purchases, recommends, or negotiates pricing on meets Stringent Regulatory Authority (SRA) standards. The team also created and manages CHAI’s rigorous quality review process to track and assess all drug and device manufacturers working with the organization.

Results
US$1.2B
in expected savings over 7 years in generic-accessible ARV markets in low-and middle-income countries through transition to DTG
12
countries provided with national guidelines revision support and clinician training on new ARV medications containing DTG
+2 years
of acceleration in development, manufacturing, regulatory approval, and commercialization of key pediatric ARV products
US$120
per person, per year expected reduction in cost of darunavir for HIV through optimized manufacturing processes
Our Work

Join Our Team

CHAI is looking for dynamic and self-motivated individuals who are committed to strengthening health systems around the world and expanding access to care and treatment of HIV/AIDS, malaria, and other illnesses.

View All CHAI Positions View Program Positions

Join Our Team

CHAI is looking for dynamic and self-motivated individuals who are committed to strengthening health systems around the world and expanding access to care and treatment of HIV/AIDS, malaria, and other illnesses.

View All CHAI Positions View Program Positions