HIV/AIDS

HIV/AIDS

The Issue

About 1.3 million people were diagnosed with HIV in 2022 alone. Even more alarming, the rate of new infections increased in several regions, including Latin America, Eastern Europe, Central Asia, the Middle East, and North Africa.

Children continue to be left behind. Of the 1.5 million children living with HIV in 2022, nearly half went untreated. And despite having the tools and medicine to ensure HIV is a chronic, manageable disease rather than a death sentence—opportunistic infections like tuberculosis and cryptococcal meningitis continue to be the leading causes of AIDS-related deaths.

There has been remarkable progress in the fight against AIDS over the past two decades. Yet, thousands of people—almost all in low- and middle-income countries—continue to die from this disease every year. If something doesn’t change, we will miss the UNAIDS global targets set for 2025.

CHAI's Approach

CHAI has played a critical role in the success of the HIV response over the last 20 years. We work closely with governments, communities of people living with HIV, international donors, and other institutions to create sustainable, effective public HIV programs in partner countries.

At the height of the AIDS crisis in the early 2000s, treating HIV cost over US$10,000 per person per year. CHAI’s pioneering work in negotiating price reductions and generic medicine licenses, together with critical efforts from partners like PEPFAR and the Global Fund, has dramatically reduced that.

Today, over 28 million people in low- and middle-income countries, including 880,000 children, have access to best-in-class treatment for less than US$45 per adult per year and under US$100 per child per year. The best available pediatric HIV medicine (pDTG) is available in over 90 countries after being developed in record time through a CHAI-led partnership. AIDS-related deaths have fallen by 64 percent since their peak in 2005. And new HIV infections have declined by 54 percent since their peak in 1996.

Ending the AIDS epidemic is within our reach. CHAI is working alongside our partners toward this objective by:

Catalyzing the rapid development and introduction of affordable HIV treatments with fewer side-effects for children and adults in Africa and Southeast Asia.

Listening to the voices, needs, and preferences of people living with HIV and ensuring they are at the center of the HIV response.

Ending childhood AIDS by scaling innovate service delivery models to better test and treat children, adolescents, and pregnant and breastfeeding people.

Preventing new infections by working with countries to introduce highlight effective interventions, such as voluntary medical male circumcision, oral pre-exposure prophylaxis (PrEP), and cabotegravir long-acting injectable (CAB-LA).

Increasing global focus on advanced HIV disease (AHD), or AIDS and implementing screening and treatment programs for children and adults across low- and middle-income countries.

Better integrating HIV care into public health systems, including mental health, sexual and reproductive health services to provide more convenient and holistic services to clients.

Results

>22M
people living with HIV in low- and middle-income countries receive best-in-class treatment, DTG, following breakthrough CHAI-brokered pricing agreement
US$45
 per patient per year to treat HIV today compared to US$10,000 20 years ago
>90
countries access pediatric DTG following the fastest-ever development and approval of a generic HIV drug, led by CHAI
45%
fewer HIV infections from 2010-2021 in CHAI partner countries due to 10M medical male circumcisions and 320K oral PrEP initiations

Spotlight

Histoplasmosis in Nigeria: Determining the Burden Among Advanced HIV Patients

In partnership with the Medical Mycology Society of Nigeria, Unitaid and CHAI are helping to better understand the burden of histoplasmosis by screening 1,000 AHD patients across ten sites in Nigeria.

Introducing optimal treatment for cryptococcal meningitis in Uganda

Presented by CHAI and the Uganda Ministry of Health. CHAI's work on accelerating access to optimal products is made possible by the generous support and partnership of Unitaid.

Join Our Team

CHAI is looking for dynamic and self-motivated individuals who are committed to strengthening health systems around the world and expanding access to care and treatment of HIV/AIDS, malaria, and other illnesses.

View All CHAI Positions View Program Positions

Join Our Team

CHAI is looking for dynamic and self-motivated individuals who are committed to strengthening health systems around the world and expanding access to care and treatment of HIV/AIDS, malaria, and other illnesses.

View All CHAI Positions View Program Positions
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